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Aiming for Longevity 

9 Hallmarks of aging

 

1. Genomic Instability      

 

2. Telomere Attrition

 

3. Epigenetic alterations

 

4. Loss of proteostasis

 

5. Deregulated Nutrient Sensing

 

6. Mitochondrial Dysfunction

 

7. Cellular Senescence -zombi cells

 

8. Stem Cell Exhaustion

 

9. Altered Intracellular Communication

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Resorces - 

1, 2, 3, 4, 5, 6, 7, 8- López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) The hallmarks of aging. Cell. 153(6), 1194-1217.

 

1 - Tobias Eisenberg, Heide Knauer et al., Induction of auto-Nagy by spermidine promotes longevity, Nature Cell Biology 2009, 11. 1305-1314

 

4 - University of Pennsylvania School of Medicine. (2015, January 22). Secrets of a clump-dissolving protein uncovered. ScienceDaily. Retrieved October 11, 2021 from www.sciencedaily.com/releases/2015/01/150122133127.htm

 

5- Reynolds, J.C., Lai, R.W., Woodhead, J.S.T. et al. MOTS-c isan exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun 12, 470 (2021). Https://doi.org/10.1038/s41467-020-20790-0

 

6, 7, 8, 9- Pizzorno J. Mitochondria-Fundamental to Life and Health. Integr Med (Encinitas). 2014;13(2):8-15.

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